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KMID : 0370220160600020073
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Yakhak Hoeji
2016 Volume.60 No. 2 p.73 ~ p.77
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Swelling of Commercial Matrix Tablets Based on Carboxymethyl Cellulose Sodium and Alginic Acid
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Kim Ki-Taek
Kim Ji-Su
Park Ju-Hwan
Lee Jae-Young
Jo Yeong-Woo
Yang Jae-Gwon
Jang Jun-Hee
Choi Eun-Sun
Kim Dae-Duk
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Abstract
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Alginic acid and carboxymethyl cellulose sodium are dietary fibers from plants. They have a swelling property and delay the gastric emptying time, thereby resulting in feeling satiated after oral administration, which may eventually contribute to loss of body weight. The goal of this study was to compare swelling property of three commercial matrix tablets based on alginic acid and carboxymethyl cellulose sodium. When the swelling was determined by the Korean Ministry of Food and Drug Safety (MFDS) guideline, the tablet prepared by direct compression method with highly viscous swelling agent showed the highest swelling in acidic conditions. Water uptake of these tablets was rapid and completed within 30 min. Moreover, when the pH was changed from 2.5 to 6.8 buffer, the water uptake was not significantly changed in all tablets.
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KEYWORD
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alginic acid, carboxymethyl cellulose sodium, tablet, swelling, water uptake
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